The COL10A1 Polyclonal Antibody (CAB18604) is specifically designed for research involving COL10A1, a type of collagen protein that is essential for the formation of cartilage and bone tissues. This antibody, derived from rabbits, is highly reactive with human samples and has been validated for use in applications such as Western blotting.COL10A1 is primarily expressed in hypertrophic chondrocytes, where it plays a key role in the development and maintenance of skeletal tissues. Dysregulation of COL10A1 has been linked to various skeletal disorders, making it an important target for investigation in musculoskeletal research.
The COL10A1 Polyclonal Antibody binds specifically to the COL10A1 protein, allowing for accurate detection and analysis in a variety of cell types.Research on COL10A1 is crucial for understanding the mechanisms underlying skeletal development and diseases such as chondrodysplasias and osteoarthritis. By studying the function and regulation of COL10A1, researchers can gain valuable insights into potential therapeutic targets for these conditions.
Antibody Name:
Anti-COL10A1 Antibody
Antibody SKU:
CAB18604
Antibody Size:
20uL, 50uL, 100uL
Application:
WB IHC
Reactivity:
Human, Rat
Host Species:
Rabbit
Immunogen:
Recombinant protein of human COL10A1.
Application:
WB IHC
Recommended Dilution:
WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:
Human, Rat
Positive Samples:
Rat lung, Rat ovary
Immunogen:
Recombinant protein of human COL10A1.
Purification Method:
Affinity purification
Storage Buffer:
Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:
IgG
Sequence:
Email for sequence
Gene ID:
1300
Uniprot:
Q03692
Cellular Location:
Calculated MW:
Observed MW:
70kDa
Western blot - COL10A1 Rabbit pAb (CAB18604)
Synonyms:
Background:
UniProt Protein Function:
Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage.
NCBI Summary:
This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD). [provided by RefSeq, Jul 2008]
