Coilin Rabbit Polyclonal Antibody (CAB6428)
- SKU:
- CAB6428
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | Coilin Rabbit Polyclonal Antibody |
SKU: | CAB6428 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 297-576 of human Coilin (NP_004636.1). |
Sequence: | KLGF SLTP SKGK TSGT TSSS SDSS AESD DQCL MSSS TPEC AAGF LKTV GLFA GRGR PGPG LSSQ TAGA AGWR RSGS NGGG QAPG ASPS VSLP ASLG RGWG REEN LFSW KGAK GRGM RGRG RGRG HPVS CVVN RSTD NQRQ QQLN DVVK NSST IIQN PVET PKKD YSLL PLLA AAPQ VGEK IAFK LLEL TSSY SPDV SDYK EGRI LSHN PETQ QVDI EILS SLPA LREP GKFD LVYH NENG AEVV EYAV TQES KITV FWKE LIDP RLII ESPS NTSS TEPA |
Tested Applications: | WB IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | CLN80; p80-coilin; Coilin |
Positive Sample: | MCF7,HepG2,293T,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Cajal body, Nucleus. |
Calculated MW: | 63kDa |
Observed MW: | 80kDa |
The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14.
Purification Method: | Affinity purification |
Gene ID: | 8161 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |