UniProt Protein Function: | COG2: Required for normal Golgi morphology and function. Belongs to the COG2 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1q42.2 Cellular Component: Golgi membrane; Golgi stack; Golgi transport complex; cytosol Molecular Function:protein binding; protein complex binding; protein transporter activity Biological Process: intracellular protein transport; intra-Golgi vesicle-mediated transport; oligosaccharide biosynthetic process; protein amino acid glycosylation; Golgi organization and biogenesis |
NCBI Summary: | This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009] |
UniProt Code: | Q14746 |
NCBI GenInfo Identifier: | 2498512 |
NCBI Gene ID: | 22796 |
NCBI Accession: | Q14746.1 |
UniProt Secondary Accession: | Q14746,Q86U99, |
UniProt Related Accession: | Q14746 |
Molecular Weight: | 738 |
NCBI Full Name: | Conserved oligomeric Golgi complex subunit 2 |
NCBI Synonym Full Names: | component of oligomeric golgi complex 2 |
NCBI Official Symbol: | COG2Â Â |
NCBI Official Synonym Symbols: | LDLCÂ Â |
NCBI Protein Information: | conserved oligomeric Golgi complex subunit 2; COG complex subunit 2; conserved oligomeric Golgi complex protein 2; brefeldin A-sensitive, peripheral Golgi protein; low density lipoprotein receptor defect C complementing; low density lipoprotein receptor defect C-complementing protein |
UniProt Protein Name: | Conserved oligomeric Golgi complex subunit 2 |
UniProt Synonym Protein Names: | Component of oligomeric Golgi complex 2; Low density lipoprotein receptor defect C-complementing protein |
Protein Family: | Conserved oligomeric Golgi complex |
UniProt Gene Name: | COG2Â Â |
UniProt Entry Name: | COG2_HUMAN |