COCH Rabbit Polyclonal Antibody (CAB6562)
- SKU:
- CAB6562
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | COCH Rabbit Polyclonal Antibody |
SKU: | CAB6562 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-260 of human COCH (NP_001128530.1). |
Sequence: | GPAG SEGA APIA ITCF TRGL DIRK EKAD VLCP GGCP LEEF SVYG NIVY ASVS SICG AAVH RGVI SNSG GPVR VYSL PGRE NYSS VDAN GIQS QMLS RWSA SFTV TKGK SSTQ EATG QAVS TAHP PTGK RLKK TPEK KTGN KDCK ADIA FLID GSFN IGQR RFNL QKNF VGKV ALML GIGT EGPH VGLV QASE HPKI EFYL KNFT SAKD VLFA IKEV GFRG GNSN TGKA LKHT AQKF FTVD A |
Tested Applications: | IHC-P IF/ICC ELISA |
Recommended Dilution: | IHC-P,1:50 - 1:100 IF/ICC,1:50 - 1:100 |
Synonyms: | DFNA9; COCH5B2; DFNB110; COCH-5B2; COCH |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, extracellular matrix, extracellular space. |
Calculated MW: | 59kDa |
Observed MW: | Refer to Figures |
The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.
Purification Method: | Affinity purification |
Gene ID: | 1690 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |