The Cochlin Polyclonal Antibody (CAB6562) is a valuable tool for researchers studying Cochlin, a protein involved in various physiological processes, particularly in the auditory system. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the Cochlin protein, this antibody enables accurate detection and analysis in a variety of cell types, making it well-suited for investigations in the fields of neuroscience and otolaryngology.Cochlin, also known as COCH, is recognized for its roles in cochlear function and extracellular matrix organization within the inner ear.
Mutations in the COCH gene have been associated with certain types of hearing loss and vestibular disorders, highlighting the importance of understanding the function and regulation of Cochlin in these conditions. Research involving the Cochlin Polyclonal Antibody can provide valuable insights into the molecular mechanisms underlying these disorders and aid in the development of potential therapeutic approaches.
Product Name:
COCH Rabbit Polyclonal Antibody
SKU:
CAB6562
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-260 of human COCH (NP_001128530.1).
The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.
Purification Method:
Affinity purification
Gene ID:
1690
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded Human prostate using COCH Rabbit pAb (CAB6562) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
