Cobra venom factor Antibody (PACO50934)
- SKU:
- PACO50934
- Product Type:
- Antibody
- Reactivity:
- Snake
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Cobra venom factor Antibody (PACO50934)
The Cobra Venom Factor Antibody (PACO50934) is a polyclonal antibody designed for research involving the Cobra Venom Factor protein. This antibody, raised in rabbits, is highly reactive with cobra venom factor samples and is validated for use in various immunoassays.The Cobra Venom Factor is a protein present in the venom of certain snake species, particularly of the Cobra family. This protein plays a critical role in the envenomation process, contributing to the toxic effects of snake venom on the body.Research involving the Cobra Venom Factor antibody can provide valuable insights into the mechanisms of snake envenomation, potentially leading to the development of new antivenom therapies.
Additionally, the antibody can be used in studies exploring the biochemical and physiological effects of cobra venom on cells and tissues.Overall, the Cobra Venom Factor Antibody (PACO50934) is a valuable tool for researchers conducting studies in toxinology, pharmacology, and venom research, offering a means to investigate the complex interactions between snake venoms and the human body.
| Antibody Name: | Cobra venom factor Antibody (PACO50934) |
| Antibody SKU: | PACO50934 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Naja kaouthia |
| Immunogen: | Recombinant Naja kaouthia Cobra venom factor protein (733-984AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in Recombinant protein. All lanes: Cobra venom factor antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. predicted band size: 45 kDa. observed band size: 45 kDa.. |
| Background: | Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity. |
| Synonyms: | Cobra venom factor (CVF) (CVFk) (Complement C3 homolog) [Cleaved into: Cobra venom factor α chain; Cobra venom factor γ chain; Cobra venom factor β chain] |
| UniProt Protein Function: | Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q91132 |
| NCBI GenInfo Identifier: | 54035743 |
| NCBI Gene ID: | |
| NCBI Accession: | Q91132.1 |
| UniProt Secondary Accession: | Q91132,Q6PQH3, Q6RHR7 |
| UniProt Related Accession: | Q91132 |
| Molecular Weight: | 44.4 kDa |
| NCBI Full Name: | Cobra venom factor |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Cobra venom factor |
| UniProt Synonym Protein Names: | Complement C3 homolog |
| Protein Family: | Cobra venom factor |
| UniProt Gene Name: | CVFÂ Â |
| UniProt Entry Name: | VCO3_NAJKA |
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