COASY Rabbit Polyclonal Antibody (CAB12179)
- SKU:
- CAB12179
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | COASY Rabbit Polyclonal Antibody |
SKU: | CAB12179 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 345-564 of human CoA synthase (COASY) (NP_079509.5). |
Sequence: | LRPP YERP ELPT CLYV IGLT GISG SGKS SIAQ RLKG LGAF VIDS DHLG HRAY APGG PAYQ PVVE AFGT DILH KDGI INRK VLGS RVFG NKKQ LKIL TDIM WPII AKLA REEM DRAV AEGK RVCV IDAA VLLE AGWQ NLVH EVWT AVIP ETEA VRRI VERD GLSE AAAQ SRLQ SQMS GQQL VEQS HVVL STLW EPHI TQRQ VEKA WALL QKRI PKTH QALD |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | NBP; DPCK; PPAT; UKR1; NBIA6; PCH12; pOV-2; CoA synthase (COASY) |
Positive Sample: | LO2,293T,A-549,SKOV3,Mouse heart,Mouse liver,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Mitochondrion matrix. |
Calculated MW: | 62kDa |
Observed MW: | 62kDa |
Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms.
Purification Method: | Affinity purification |
Gene ID: | 80347 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |