The CoA Synthetic (COASY) Polyclonal Antibody (CAB12179) is a vital tool for researchers studying the COASY protein, which plays a crucial role in coenzyme A biosynthesis and lipid metabolism. This antibody, developed using rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blotting applications.COASY is essential for cellular energy metabolism and is involved in various physiological processes, making it a key target for research in metabolic disorders, neurodegenerative diseases, and cancer. By binding specifically to the COASY protein, this polyclonal antibody enables precise detection and analysis in a range of cell types, making it an ideal choice for investigations in biochemistry and molecular biology.
Understanding the function and regulation of COASY is fundamental in elucidating its role in health and disease, and this antibody provides a reliable tool for unravelling the complex mechanisms underlying COASY-mediated cellular processes. Researchers can leverage the capabilities of this antibody to explore the potential therapeutic applications of targeting COASY in metabolic and neurological conditions, paving the way for innovative interventions in precision medicine and drug discovery.
Product Name:
COASY Rabbit Polyclonal Antibody
SKU:
CAB12179
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 345-564 of human CoA synthase (COASY） (NP_079509.5).
Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms.
Purification Method:
Affinity purification
Gene ID:
80347
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CoA synthase (COASY） Rabbit pAb (CAB12179) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
