The COA6 Antibody (PACO36110) is a polyclonal antibody specifically designed for research involving COA6, a protein known to play a crucial role in cytochrome c oxidase assembly. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in applications such as Western blot and immunohistochemistry.COA6 is a key player in the mitochondrial respiratory chain and has been implicated in various diseases related to mitochondrial dysfunction. Research on COA6 is essential for understanding its role in mitochondrial function and its potential as a therapeutic target for mitochondrial disorders.
This antibody enables accurate detection and analysis of COA6 in different cell types, making it an invaluable tool for studies in mitochondrial biology, biochemistry, and disease research. Its high specificity and sensitivity make it ideal for scientists looking to delve deeper into the mechanisms underlying mitochondrial dysfunction and develop new strategies for treating related disorders.
Antibody Name:
COA6 Antibody (PACO36110)
Antibody SKU:
PACO36110
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Cytochrome c oxidase assembly factor 6 homolog protein (1-125AA)
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO36110 at dilution of 1:100.
Background:
Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV.
Synonyms:
Cytochrome c oxidase assembly factor 6 homolog, COA6, C1orf31
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the cytochrome c oxidase subunit 6B family. The encoded protein associates with cytochrome c oxidase may act has an cytochrome c oxidase mitochondrial respiratory complex VI assembly factor. Mutations in this gene may be associated with fatal infantile cardiomyopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
