The CNTFR Polyclonal Antibody (CAB2700) is specifically designed for research involving the CNTFR protein, which is a cell surface receptor implicated in the regulation of neuronal development and survival. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the CNTFR protein, this antibody enables detection and analysis in various cell types, making it an ideal tool for studies in neuroscience and neurodegenerative diseases.The CNTFR protein, also known as ciliary neurotrophic factor receptor, plays a crucial role in promoting the growth and survival of neuronal cells through activation of various signaling pathways.
Its significance in neuronal development and function makes it a valuable target for research into conditions such as neurodegenerative disorders, nerve injuries, and brain tumors. Understanding the mechanisms of CNTFR activation and signaling is essential for the development of targeted therapies aimed at promoting neuronal health and combating neurodegenerative conditions.
Product Name:
CNTFR Rabbit Polyclonal Antibody
SKU:
CAB2700
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 90-342 of human CNTFR (NP_671693.1).
This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
1271
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CNTFR antibody (CAB2700) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
