The CNPase Polyclonal Antibody (CAB21357) is a crucial tool for researchers studying CNPase, a key enzyme essential for myelin formation in the central nervous system. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By binding to the CNPase protein, researchers can detect and analyze its expression in a variety of cell types, making it ideal for studies in neuroscience and neurological disorders.CNPase, or 2',3'-cyclic nucleotide 3'-phosphodiesterase, is essential for the synthesis and maintenance of myelin, the insulating layer around nerves that is critical for proper nerve function.
Dysregulation of CNPase has been linked to various neurological disorders, including multiple sclerosis and leukodystrophies. By understanding the role of CNPase, researchers can work towards developing targeted therapies for these debilitating conditions.Overall, the CNPase Polyclonal Antibody is a valuable tool for researchers looking to study myelination processes and investigate the role of CNPase in neurological diseases. Its high reactivity and specificity make it an essential component of any research project focused on understanding and treating disorders of the central nervous system.
Product Name:
CNPase Polyclonal Antibody
SKU:
CAB21357
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 152-421 of human CNPase (NP_149124.3).
Predicted to enable 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity. Involved in substantia nigra development. Located in several cellular components, including extracellular space; microtubule; and plasma membrane. Implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Biomarker of alcoholic liver cirrhosis; multiple sclerosis; and restless legs syndrome.
Purification Method:
Affinity purification
Gene ID:
1267
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using CNPase Rabbit pAb (CAB21357) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 15s.
