The CNOT8 Polyclonal Antibody (CAB8058) is a valuable tool for researchers studying the CNOT8 protein, which plays a crucial role in mRNA degradation and gene expression regulation. This antibody, raised in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications.The CNOT8 protein is a component of the CCR4-NOT complex, which is involved in mRNA deadenylation and degradation. By targeting CNOT8, researchers can investigate its role in post-transcriptional gene regulation and its impact on cellular processes such as cell proliferation, differentiation, and apoptosis.
With its ability to specifically bind to the CNOT8 protein, this polyclonal antibody enables accurate detection and analysis in various cell types, making it an excellent tool for studies in molecular biology and gene expression research. Understanding the function of CNOT8 is essential for unraveling its contribution to normal cellular physiology and its potential implications in disease development and progression.
Product Name:
CNOT8 Rabbit Polyclonal Antibody
SKU:
CAB8058
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-292 of human CNOT8 (NP_004770.4).
Enables poly(A)-specific ribonuclease activity. Involved in exonucleolytic catabolism of deadenylated mRNA and positive regulation of cell population proliferation. Located in nucleus. Part of CCR4-NOT complex.
Purification Method:
Affinity purification
Gene ID:
9337
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CNOT8 antibody (CAB8058) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
