The CNOT7 Polyclonal Antibody (CAB8959) is a crucial tool for research involving CNOT7, a protein related to mRNA deadenylation and decay processes. This high-quality antibody is produced in rabbits and has been extensively validated for use in Western blot applications, ensuring reliable and consistent results. By specifically binding to the CNOT7 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in molecular biology and gene regulation.CNOT7, also known as the Ccr4-Not complex subunit 7, is essential for controlling gene expression by regulating the turnover of mRNA molecules. Its role in mRNA degradation and deadenylation makes it a key player in numerous cellular processes, including RNA metabolism, protein synthesis, and gene regulation.
Research on CNOT7 is vital for understanding how cells maintain proper gene expression and respond to changes in their environment, with implications for various fields such as developmental biology, cancer biology, and neuroscience.The CNOT7 Polyclonal Antibody offers researchers a valuable tool for studying the functions and mechanisms of CNOT7 in diverse biological contexts. Its high specificity and sensitivity make it suitable for detecting endogenous levels of CNOT7 in cell lysates and tissue samples, allowing for detailed investigations into its roles in gene expression and mRNA regulation. By targeting CNOT7, this antibody facilitates the exploration of new pathways and targets for therapeutic interventions in diseases related to aberrant gene expression and mRNA stability
Product Name:
CNOT7 Rabbit Polyclonal Antibody
SKU:
CAB8959
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 90-160 of human CNOT7 (NP_037486.2).
The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X.
Purification Method:
Affinity purification
Gene ID:
29883
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CNOT7 Rabbit pAb (CAB8959) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
