The CNOT1 Polyclonal Antibody (CAB5969) is a valuable tool for researchers studying CNOT1, a key component of the CCR4-NOT complex involved in mRNA degradation and transcriptional regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting CNOT1 in human samples, making it suitable for use in Western blot applications.CNOT1 is essential for controlling gene expression by regulating mRNA stability and turnover, playing a crucial role in processes such as cell proliferation, differentiation, and development. Dysregulation of CNOT1 has been linked to various diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions and biomarker discovery.
By utilizing the CNOT1 Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of CNOT1 in different biological systems, facilitating advancements in the fields of molecular biology, genetics, and disease pathology. Its versatility and reliability make it an essential tool for studies focusing on RNA metabolism and gene expression dynamics.
Product Name:
CNOT1 Rabbit Polyclonal Antibody
SKU:
CAB5969
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2137-2376 of human CNOT1 (NP_057368.3).
Enables armadillo repeat domain binding activity; molecular adaptor activity; and nuclear receptor binding activity. Contributes to poly(A)-specific ribonuclease activity. Involved in several processes, including negative regulation of signal transduction; positive regulation of cytoplasmic mRNA processing body assembly; and regulation of gene expression. Located in P-body and cytosol. Part of CCR4-NOT complex. Implicated in holoprosencephaly.
Purification Method:
Affinity purification
Gene ID:
23019
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using CNOT1 Rabbit pAb (CAB5969) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
