CNN2 Antibody (PACO23399)
- SKU:
- PACO23399
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CNN2 Antibody (PACO23399)
The CNN2 Polyclonal Antibody (PAC02399) is a valuable tool for researchers studying CNN2, a protein involved in actin cytoskeleton reorganization and cell migration. This antibody, produced in rabbits, has been rigorously tested and is highly reactive with human samples, making it ideal for use in Western blot applications. By binding to the CNN2 protein, this antibody allows for the detection and analysis of CNN2 in various cell types, providing insights into its role in cell movement and signaling pathways.CNN2, also known as calponin 2, is essential for the regulation of actin dynamics and is implicated in processes such as cell migration, adhesion, and contraction. Its involvement in these cellular functions highlights its importance in various physiological and pathological processes, including cancer metastasis and cardiovascular diseases.
Research focusing on CNN2 can uncover potential targets for therapeutic interventions aimed at modulating cell migration and invasion in disease states.By using the CNN2 Polyclonal Antibody (PAC02399), researchers can gain a better understanding of the molecular mechanisms underlying CNN2 function and its impact on cellular processes. This antibody is a valuable tool for studies in cell biology, cancer research, and other fields where CNN2 plays a crucial role, ultimately contributing to advancements in our understanding of disease development and potential therapeutic strategies.
| Antibody Name: | CNN2 Antibody (PACO23399) |
| Antibody SKU: | PACO23399 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IF:1:100-1:500 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from internal of human CNN2. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HUVEC cells, using CNN2 antibody. |
 | Immunofluorescence analysis of A549 cells, using CNN2 antibody. |
| Background: | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
| Synonyms: | Calponin H2; smooth muscle; CLP2; CNN2; Neutral calponin |
| UniProt Protein Function: | calponin 2: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. Belongs to the calponin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Actin-binding; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: cytoskeleton; focal adhesion; intercellular junction; membrane; stress fiber Biological Process: cytoskeleton organization and biogenesis; regulation of actin filament-based process |
| NCBI Summary: | The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Several pseudogenes of this gene have been identified, and are present on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015] |
| UniProt Code: | Q99439 |
| NCBI GenInfo Identifier: | 6226844 |
| NCBI Gene ID: | 1265 |
| NCBI Accession: | Q99439.4 |
| UniProt Secondary Accession: | Q99439,Q92578, A5D8U8, A6NFI4, D6W5X9, |
| UniProt Related Accession: | Q99439 |
| Molecular Weight: | 29,500 Da |
| NCBI Full Name: | Calponin-2 |
| NCBI Synonym Full Names: | calponin 2 |
| NCBI Official Symbol: | CNN2Â Â |
| NCBI Protein Information: | calponin-2 |
| UniProt Protein Name: | Calponin-2 |
| UniProt Synonym Protein Names: | Calponin H2, smooth muscle; Neutral calponin |
| Protein Family: | Calponin |
| UniProt Gene Name: | CNN2Â Â |
| UniProt Entry Name: | CNN2_HUMAN |
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