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CNN2 Antibody (PACO08487)

SKU:
PACO08487
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
Frequently bought together:

Description

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CNN2 Antibody (PACO08487)

The CNN2 Polyclonal Antibody (PACO08487) is a valuable tool for researchers studying CNN2, a protein involved in smooth muscle contraction and regulation. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting. By targeting the CNN2 protein, this antibody allows for the detection and analysis of CNN2 expression in different cell types, facilitating research in areas such as cardiovascular health and muscle physiology.CNN2, also known as calponin 2, plays a key role in controlling the contractility of smooth muscle cells, making it a crucial player in processes such as blood vessel dilation and airway constriction.

Dysregulation of CNN2 expression has been implicated in diseases like hypertension, asthma, and gastrointestinal disorders, highlighting its potential as a therapeutic target. By studying the function of CNN2, researchers can uncover new insights into the mechanisms underlying these conditions and potentially develop novel treatment strategies.

Antibody Name:CNN2 Antibody (PACO08487)
Antibody SKU:PACO08487
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IF
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human CNN2
Form:Liquid
Storage Buffer:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:calponin 2;
UniProt Protein Function:calponin 2: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. Belongs to the calponin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytoskeleton; focal adhesion; intercellular junction; membrane; stress fiber

Biological Process: cytoskeleton organization and biogenesis; regulation of actin filament-based process

NCBI Summary:The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Several pseudogenes of this gene have been identified, and are present on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]
UniProt Code:Q99439
NCBI GenInfo Identifier:6226844
NCBI Gene ID:1265
NCBI Accession:Q99439.4
UniProt Secondary Accession:Q99439,Q92578, A5D8U8, A6NFI4, D6W5X9,
UniProt Related Accession:Q99439
Molecular Weight:29,500 Da
NCBI Full Name:Calponin-2
NCBI Synonym Full Names:calponin 2
NCBI Official Symbol:CNN2  
NCBI Protein Information:calponin-2
UniProt Protein Name:Calponin-2
UniProt Synonym Protein Names:Calponin H2, smooth muscle; Neutral calponin
Protein Family:Calponin
UniProt Gene Name:CNN2  
UniProt Entry Name:CNN2_HUMAN

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