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CNN2 Antibody (PACO00503)

SKU:
PACO00503
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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CNN2 Antibody (PACO00503)

The CNN2 Monoclonal Antibody (PAC00503) is a vital tool for researchers studying CNN2, a protein involved in smooth muscle contraction and regulation. This antibody is specifically designed for use in immunohistochemistry applications, providing high sensitivity and specificity when detecting CNN2 in tissue samples. CNN2, also known as calponin 2, is essential for maintaining the contractile function of smooth muscle cells and plays a crucial role in various physiological processes, including blood pressure regulation and vascular function.

Dysregulation of CNN2 has been linked to diseases such as hypertension and atherosclerosis, making it a promising therapeutic target for cardiovascular research.The CNN2 Monoclonal Antibody (PAC00503) offers researchers a reliable tool for studying the expression and localization of CNN2 in tissues, contributing valuable insights into its function and potential implications in cardiovascular health. Its high specificity and sensitivity make it a valuable asset for investigations into smooth muscle biology and cardiovascular diseases.

Antibody Name:CNN2 Antibody
Antibody SKU:PACO00503
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IF
Recommended Dilutions:WB:1:500-1:2000, IF:1:200-1:1000
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from the Internal region of human Calponin 2.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:CNN2; Calponin-2; Calponin H2; smooth muscle; Neutral calponin
UniProt Protein Function:calponin 2: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. Belongs to the calponin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytoskeleton; focal adhesion; intercellular junction; membrane; stress fiber

Biological Process: cytoskeleton organization and biogenesis; regulation of actin filament-based process

NCBI Summary:The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Several pseudogenes of this gene have been identified, and are present on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]
UniProt Code:Q99439
NCBI GenInfo Identifier:6226844
NCBI Gene ID:1265
NCBI Accession:Q99439.4
UniProt Secondary Accession:Q99439,Q92578, A5D8U8, A6NFI4, D6W5X9,
UniProt Related Accession:Q99439
Molecular Weight:29,500 Da
NCBI Full Name:Calponin-2
NCBI Synonym Full Names:calponin 2
NCBI Official Symbol:CNN2  
NCBI Protein Information:calponin-2
UniProt Protein Name:Calponin-2
UniProt Synonym Protein Names:Calponin H2, smooth muscle; Neutral calponin
Protein Family:Calponin
UniProt Gene Name:CNN2  
UniProt Entry Name:CNN2_HUMAN

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