CNMD Polyclonal Antibody (CAB23878)
- SKU:
- CAB23878
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | CNMD Polyclonal Antibody |
SKU: | CAB23878 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant protein of human CNMD. |
Sequence: | VHYT MSIN GKLQ DGSM EIDA GNNL ETFK MGSG AEEA IAVN DFQN GITG IRFA GGEK CYIK AQVK ARIP EVGA VTKQ SISS KLEG KIMP VKYE ENSL IWVA VDQP VKDN SFLS SKVL ELCG DLPI FWLK PTYP KEIQ RERR EVVR KIVP TTTK RPHS GPRS NPGA GRLN NETR PSVQ EDSQ AFNP DNPY HQQE GESM TFDP RLDH EGIC CIEC RRSY THCQ KICE PLGG YYPW PYNY QGCR SACR VIMP CSWW VARI LGMV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | CHM1; CHM-I; LECT1; BRICD3; MYETS1; CNMD |
Positive Sample: | 293T |
Conjugate: | Unconjugated |
Cellular Localization: | Endomembrane system, Secreted, Single-pass membrane protein, extracellular matrix, extracellular space. |
Calculated MW: | 37kDa |
Observed MW: | 42kDa |
This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 11061 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |