The CNMD Polyclonal Antibody is a powerful research tool designed for studying the CNMD protein, a critical component in immune regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the CNMD protein, researchers can detect and analyze its expression in various cell types, making it an invaluable resource for investigations in immunology and cancer research.CNMD, also known as a modulator of immune responses, plays a key role in maintaining immune balance by regulating inflammation and suppressing allergic reactions.
Its involvement in immune response modulation positions it as a promising target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of CNMD is essential for the development of therapeutic interventions that manipulate immune responses in these disease contexts.
This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
11061
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of normal 293T cells and 293T transfected with CNMD protein, using CNMD Rabbit pAb (CAB23878) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
