The CNKSR1 Polyclonal Antibody (PAC021922) is a valuable tool for research involving CNKSR1, a scaffold protein involved in cell signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It specifically binds to the CNKSR1 protein, allowing for accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in cell biology and signal transduction research.CNKSR1 functions as an adaptor protein, playing a key role in the regulation of signaling cascades that are essential for cell growth, differentiation, and survival.
Its involvement in various cellular processes makes it a promising target for research aimed at understanding the mechanisms underlying diseases such as cancer, developmental disorders, and neurological conditions. Investigating the role of CNKSR1 is crucial for uncovering new therapeutic targets and strategies for treating these conditions.
Antibody Name:
CNKSR1 Antibody (PACO21922)
Antibody SKU:
PACO21922
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from internal of human CNKR1.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from COLO cells, using CNKR1 antibody.
Background:
May function as an adapter protein or regulator of Ras signaling pathways. The MGC Project Team, Genome Res. 14:2121-2127(2004).
Synonyms:
Connector enhancer of KSR1; hCNK1; Connector enhancer of KSR-like; CNK homolog protein 1;
UniProt Protein Function:
CNK1: a RAF-binding multidomain protein required for RAS signaling. Contains several protein-protein interaction domains. Its PH domain interacts with Rho in a GTP-dependent manner. Associates with Rhophilin and RalGDS, Rho and Ras effector molecules. Two alternatively spliced isoforms have been described.Protein type: G protein regulator, misc.; Adaptor/scaffoldChromosomal Location of Human Ortholog: 1p36.11Cellular Component: plasma membrane; cell cortex; intercellular junctionMolecular Function: protein binding, bridgingBiological Process: Ras protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; Rho protein signal transduction
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein containing several motifs involved in protein-protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
