The CNKSR1 Polyclonal Antibody (PACO08484) is a valuable tool for researchers studying CNKSR1, a protein involved in various cellular processes including signal transduction and regulation of gene expression. This antibody, produced in rabbits, shows high specificity and sensitivity in detecting CNKSR1 protein in human samples, making it ideal for Western blot applications.CNKSR1, also known as connector enhancer of kinase suppressor of Ras 1, is a key player in signal transduction pathways that control cell growth, differentiation, and survival.
Its dysregulation has been implicated in diseases like cancer, making it a potential therapeutic target. By using the CNKSR1 Polyclonal Antibody, researchers can uncover the role of CNKSR1 in cancer development and progression, paving the way for novel treatment strategies targeting this pathway.
connector enhancer of kinase suppressor of Ras 1;CNKSR1;CNK;CNK1;KSR ;
UniProt Protein Function:
CNK1: a RAF-binding multidomain protein required for RAS signaling. Contains several protein-protein interaction domains. Its PH domain interacts with Rho in a GTP-dependent manner. Associates with Rhophilin and RalGDS, Rho and Ras effector molecules. Two alternatively spliced isoforms have been described.Protein type: G protein regulator, misc.; Adaptor/scaffoldChromosomal Location of Human Ortholog: 1p36.11Cellular Component: plasma membrane; cell cortex; intercellular junctionMolecular Function: protein binding, bridgingBiological Process: Ras protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; Rho protein signal transduction
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein containing several motifs involved in protein-protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
