The CNIH4 Polyclonal Antibody (PAC042006) is a highly specific research tool designed for studying CNIH4, a transmembrane protein involved in ion channel regulation and synaptic transmission. This antibody, produced in rabbits, demonstrates strong reactivity with human, mouse, and rat samples and is validated for use in various applications including Western blot and immunohistochemistry.CNIH4, a member of the cornichon family of proteins, plays a key role in modulating the activity of ion channels in neurons, contributing to synaptic plasticity and neurotransmission.
Research on CNIH4 has implications for understanding neural circuit function and could lead to insights into neurological disorders such as epilepsy, Alzheimer's disease, and schizophrenia.By targeting CNIH4, researchers can investigate its role in ion channel regulation and synaptic transmission, providing valuable insights into neural function and potential therapeutic targets for neurological conditions. The CNIH4 Polyclonal Antibody is a valuable tool for studies in neuroscience, neurology, and drug development.
Western blot. All lanes: CNIH4 antibody at 0.3µg/ml. Lane 1: A431 whole cell lysate. Lane 2: U251 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 17, 11 kDa. Observed band size: 17 kDa.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO42006 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO42006 at dilution of 1:100.
Background:
Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery.
Synonyms:
Protein cornichon homolog 4 (CNIH-4) (Cornichon family AMPA receptor auxiliary protein 4), CNIH4
UniProt Protein Function:
CNIH4: Belongs to the cornichon family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 1q42.11Cellular Component: endoplasmic reticulum; ER-Golgi intermediate compartment; integral to membraneMolecular Function: CCR5 chemokine receptor binding; protein bindingBiological Process: ER to Golgi vesicle-mediated transport; protein transport
