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CNGB1 Antibody (PACO59085)

SKU:
PACO59085
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • CNGB1 Antibody PACO59085
  • CNGB1 Antibody PACO59085
  • CNGB1 Antibody PACO59085
€339

Description

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CNGB1 Antibody (PACO59085)

The CNGb1 Polyclonal Antibody (PACO59085) is a crucial tool for researchers studying CNGb1, a key protein involved in signal transduction in sensory neurons. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the CNGb1 protein, this antibody enables precise detection and analysis in various cell types, making it an invaluable asset for studies in sensory biology and neurology.CNGb1, also known as cyclic nucleotide-gated channel beta-1, plays a vital role in mediating sensory perception by converting chemical signals into electrical signals in sensory neurons.

Understanding the function of CNGb1 is essential for unraveling the mechanisms underlying sensory processing and perception. Research into CNGb1 may have implications for conditions related to sensory dysfunction, such as sensory neuropathies and sensory processing disorders.Overall, the CNGb1 Polyclonal Antibody (PACO59085) offers researchers a reliable tool for investigating the role of CNGb1 in sensory signal transduction pathways, opening up new possibilities for advancing our understanding of sensory biology and potentially identifying novel therapeutic targets for sensory-related disorders.

Antibody Name:CNGB1 Antibody (PACO59085)
Antibody SKU:PACO59085
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Cyclic nucleotide-gated cation channel beta-1 protein (131-253AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern Blot. Positive WB detected in: Hela whole cell lysate, A549 whole cell lysate, 293T whole cell lysate. All lanes: CNGB1 antibody at 4.6µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 140, 71, 33 kDa. Observed band size: 140 kDa.
Product ImageImmunofluorescence staining of A549 cells with PACO59085 at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Product ImageIHC image of PACO59085 diluted at 1:200 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP.
Synonyms:Cyclic nucleotide-gated cation channel beta-1 (Cyclic nucleotide-gated cation channel 4) (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel gamma) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel beta-1) (CNG channel beta-1) (Glutamic acid, rich protein) (GARP), CNGB1, CNCG2 CNCG3L CNCG4 RCNC2
UniProt Protein Function:Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP.
UniProt Protein Details:
NCBI Summary:In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in this gene are a cause of cause of retinitis pigmentosa type 45. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
UniProt Code:Q14028
NCBI GenInfo Identifier:208431781
NCBI Gene ID:1258
NCBI Accession:NP_001129111.1
UniProt Secondary Accession:Q14028,O43636, Q13059, Q14029, Q9UMG2, H3BN09
UniProt Related Accession:Q14028
Molecular Weight:139,179 Da
NCBI Full Name:cyclic nucleotide-gated cation channel beta-1 isoform b
NCBI Synonym Full Names:cyclic nucleotide gated channel beta 1
NCBI Official Symbol:CNGB1  
NCBI Official Synonym Symbols:CNG4; GAR1; GARP; RP45; CNCG2; CNCG4; GARP2; RCNC2; RCNCb; CNCG3L; CNGB1B; RCNCbeta  
NCBI Protein Information:cyclic nucleotide-gated cation channel beta-1
UniProt Protein Name:Cyclic nucleotide-gated cation channel beta-1
UniProt Synonym Protein Names:Cyclic nucleotide-gated cation channel 4; CNG channel 4; CNG-4; CNG4; Cyclic nucleotide-gated cation channel gamma; Cyclic nucleotide-gated cation channel modulatory subunit; Cyclic nucleotide-gated channel beta-1; CNG channel beta-1; Glutamic acid-rich protein; GARP
Protein Family:Cyclic nucleotide-gated cation channel
UniProt Gene Name:CNGB1  
UniProt Entry Name:
Antibodies
CNGB1 Antibody (PACO06363)
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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