The CNGA1 Polyclonal Antibody (PAC061298) is a valuable tool for researchers studying CNGA1, a key protein involved in the visual and olfactory signal transduction pathways. This antibody is raised in rabbits and has a high reactivity with human samples, making it suitable for use in Western blot applications. By binding to the CNGA1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in sensory biology and neurology research.CNGA1, also known as the cyclic nucleotide-gated ion channel alpha-1 subunit, plays a crucial role in mediating the electrical signal transduction in sensory neurons.
Its involvement in signal amplification and transmission makes it a valuable target for research into disorders affecting sensory perception and signal processing. By understanding the function and regulation of CNGA1, researchers can gain valuable insights into conditions such as retinal degeneration, anosmia, and other sensory processing disorders.Overall, the CNGA1 Polyclonal Antibody (PAC061298) is a reliable tool for researchers looking to explore the role of CNGA1 in sensory biology and neurology, opening up new avenues for understanding and potentially treating a range of sensory-related disorders.
Antibody Name:
CNGA1 Antibody (PACO61298)
Antibody SKU:
PACO61298
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human cGMP-gated cation channel alpha-1 protein (586-690AA)
Immunofluorescence staining of HepG2 cells with PACO61298 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.CautionIt is uncertain whether Met-1 or Met-5 is the initiator.
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
