The CNGA1 Polyclonal Antibody (PACO22261) is a valuable tool for researchers studying CNGA1, a key protein involved in the function of cyclic nucleotide-gated ion channels. This antibody, produced in rabbits, exhibits high reactivity with human samples and is specifically validated for use in techniques such as Western blotting.CNGA1 is known for its role in mediating sensory transduction in various cell types, making it an intriguing target for investigation in the fields of neurobiology and sensory physiology. By binding to the CNGA1 protein, this antibody enables accurate detection and analysis of CNGA1 expression levels in different cellular environments.
Moreover, the functional significance of CNGA1 in ion channel regulation highlights its potential relevance in studying conditions related to sensory processing and signal transduction. Research efforts focused on understanding the mechanisms involving CNGA1 could provide valuable insights into the pathophysiology of sensory disorders and pave the way for the development of targeted therapeutic interventions.
Antibody Name:
CNGA1 Antibody (PACO22261)
Antibody SKU:
PACO22261
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human CNGA1.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HepG2 cells and K562 cells, using CNGA1 antibody.
Background:
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.CautionIt is uncertain whether Met-1 or Met-5 is the initiator.
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
