The CNGA1 Antibody (PAC017711) is a high-quality polyclonal antibody designed for research involving CNGA1, a key protein involved in the function of cyclic nucleotide-gated ion channels. This antibody, produced in rabbits, specifically targets the CNGA1 protein, allowing for accurate detection and analysis in various experimental settings.CNGA1 is essential for the regulation of ion flow in response to cyclic nucleotide signaling, playing a crucial role in processes such as visual and olfactory signal transduction. Research involving CNGA1 is particularly relevant in the study of sensory physiology, as well as in exploring the mechanisms underlying various sensory disorders.
Validated for use in Western blot applications, the CNGA1 Antibody (PAC017711) offers researchers a reliable tool for investigating the function and expression of CNGA1 in different cell types and tissues. Its reactivity with human samples makes it especially valuable for studies focused on human biology and disease mechanisms.By providing a means to detect and analyze CNGA1, this antibody empowers researchers to gain a deeper understanding of the role this protein plays in cellular signaling pathways and sensory function. Its versatility and specificity make it an invaluable resource for advancing research in areas such as neuroscience, ophthalmology, and sensory biology.
Antibody Name:
CNGA1 Antibody (PACO17711)
Antibody SKU:
PACO17711
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:500-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human CNGA1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17711(CNGA1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms:
cyclic nucleotide gated channel α 1
UniProt Protein Function:
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.CautionIt is uncertain whether Met-1 or Met-5 is the initiator.
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
