The CNGA1 Polyclonal Antibody (PAC017710) is a valuable tool for researchers studying CNGA1, a key protein involved in regulating ion channels in various cell types. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications. By targeting the CNGA1 protein, researchers can analyze its expression and function in different cell types, particularly in the context of ion channel regulation.CNGA1 is essential for mediating ion flow in cells, making it a crucial player in processes like sensory transduction and neuronal signaling.
Dysregulation of CNGA1 has been linked to various diseases and disorders, including sensory impairments and neurological conditions. By studying CNGA1 with this antibody, researchers can gain valuable insights into its role in health and disease, potentially leading to the development of novel therapeutic strategies targeting ion channel function.
Antibody Name:
CNGA1 Antibody (PACO17710)
Antibody SKU:
PACO17710
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human CNGA1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17710(CNGA1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms:
cyclic nucleotide gated channel α 1
UniProt Protein Function:
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.CautionIt is uncertain whether Met-1 or Met-5 is the initiator.
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
