CMTM8 Antibody (PACO37646)
- SKU:
- PACO37646
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CMTM8 Antibody (PACO37646)
The CMTM8 Polyclonal Antibody (PAC037646) is a reliable tool for research involving CMTM8, a protein involved in immune regulation and cancer development. This antibody is produced in rabbits and is highly specific for human samples, making it suitable for a variety of research applications, including Western blot analysis.CMTM8 is known for its role in modulating immune responses and its potential involvement in cancer progression. By targeting CMTM8 with this antibody, researchers can investigate its function in different cell types and gain insight into its implications in immunology and oncology.
Furthermore, understanding the mechanisms by which CMTM8 influences immune regulation and cancer development is essential for developing targeted therapies and identifying potential biomarkers for monitoring disease progression. The CMTM8 Polyclonal Antibody is a valuable tool for researchers aiming to advance their understanding of these complex biological processes.
| Antibody Name: | CMTM8 Antibody (PACO37646) |
| Antibody SKU: | PACO37646 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human CKLF-like MARVEL transmembrane domain-containing protein 8 protein (1-39AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescent analysis of HepG2 cells using PACO37646 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Synonyms: | CKLF-like MARVEL transmembrane domain-containing protein 8 (Chemokine-like factor superfamily member 8), CMTM8, CKLFSF8 |
| UniProt Protein Function: | CMTM8: a widely distributed protein with four transmembrane regions and a MARVEL domain. Associates with the epidermal growth factor receptor. Transfection into several cell lines suppresses EGF-induced cell proliferation and increases the rate of receptor endocytosis. The lack of EGFR-mediated signaling induces cells to undergo apoptosis via caspase-dependent and -independent pathways. Knockdown of CMTM8 by siRNA promotes cell proliferation and delayed EGFR endocytosis. Two splice-variant human isoforms have been reproted. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 3p22.3 Cellular Component: cytoplasm; extracellular space; integral to membrane; nucleoplasm Molecular Function:cytokine activity Biological Process: chemotaxis |
| NCBI Summary: | This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor, and plays a role in regulating the migration of tumor cells. The encoded protein is thought to function as a a negative regulator of epidermal growth factor-induced signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016] |
| UniProt Code: | Q8IZV2 |
| NCBI GenInfo Identifier: | 145559454 |
| NCBI Gene ID: | 152189 |
| NCBI Accession: | Q8IZV2.2 |
| UniProt Secondary Accession: | Q8IZV2,Q8IW01, A5D6I7, |
| UniProt Related Accession: | Q8IZV2 |
| Molecular Weight: | 12,739 Da |
| NCBI Full Name: | CKLF-like MARVEL transmembrane domain-containing protein 8 |
| NCBI Synonym Full Names: | CKLF like MARVEL transmembrane domain containing 8 |
| NCBI Official Symbol: | CMTM8Â Â |
| NCBI Official Synonym Symbols: | CKLFSF8; CKLFSF8-V2Â Â |
| NCBI Protein Information: | CKLF-like MARVEL transmembrane domain-containing protein 8 |
| UniProt Protein Name: | CKLF-like MARVEL transmembrane domain-containing protein 8 |
| UniProt Synonym Protein Names: | Chemokine-like factor superfamily member 8 |
| Protein Family: | CKLF-like MARVEL transmembrane domain-containing protein |
| UniProt Gene Name: | CMTM8Â Â |
| UniProt Entry Name: | CKLF8_HUMAN |
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