The CMTM5 Polyclonal Antibody (PAC017942) is a vital tool for studying CMTM5, a promising tumor suppressor gene involved in cancer development and progression. This antibody, generated through rabbit immunization, exhibits exceptional reactivity towards human samples and is recommended for use in Western blot applications. By targeting the CMTM5 protein, researchers can accurately detect and investigate its expression levels in various cell types, offering valuable insights into its role in cancer biology.CMTM5, a member of the CMTM family, has been identified as a key player in regulating cell growth, apoptosis, and metastasis, making it a valuable target for cancer research.
Studies have shown that alterations in CMTM5 expression are associated with tumorigenesis, suggesting its potential as a diagnostic marker and therapeutic target in various cancer types. Investigating the functions of CMTM5 is essential for advancing our understanding of cancer biology and developing innovative treatment strategies for cancer patients.
Antibody Name:
CMTM5 Antibody (PACO17942)
Antibody SKU:
PACO17942
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human CMTM5
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 12+15%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: PACO17942(CMTM5 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
Background:
This gene belongs to the chemokine-like factor gene superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. Highly expressed in the brain.
CMTM5: a member of the chemokine-like factor gene superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Protein Details:
Protein type:Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: extracellular space; integral to membrane
Molecular Function:cytokine activity
Biological Process: negative regulation of myoblast differentiation; chemotaxis
NCBI Summary:
This gene encodes a member of the chemokine-like factor superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. The encoded protein may exhibit tumor suppressor activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
