The CMBL Antibody (PAC039282) is a high-quality polyclonal antibody specifically designed for research involving Carboxymethylenebutenolidase (CMBL), an enzyme involved in the metabolism of various drugs and xenobiotics. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications.CMBL, a member of the hydrolase family, is known to hydrolyze prodrugs such as 5-nitroimidazole, impacting their activation and therapeutic efficacy. Understanding the role of CMBL in drug metabolism is crucial for optimizing drug therapies and minimizing potential drug interactions.
The CMBL Antibody (PAC039282) binds specifically to the CMBL protein, enabling accurate detection and analysis in different cell types and tissues. Its reliability and specificity make it an essential tool for research in drug metabolism, pharmacology, and personalized medicine.Researchers studying drug metabolism, pharmacokinetics, and drug-drug interactions will find the CMBL Antibody (PAC039282) to be a valuable asset in their experiments. By elucidating the mechanisms by which CMBL influences drug metabolism, researchers can contribute to the development of safer and more effective therapies for various medical conditions.
Western blot. All lanes: CMBL antibody at 1µg/ml. Lane 1: Mouse kidney tissue. Lane 2: Mouse liver tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 29 kDa. Observed band size: 29, 25 kDa.
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO39282 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO39282 at dilution of 1:100.
Background:
Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin.
CMBL: Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. Belongs to the dienelactone hydrolase family.Protein type: Hydrolase; EC 3.1.-.-Chromosomal Location of Human Ortholog: 5p15.2Cellular Component: cytosolMolecular Function: hydrolase activityBiological Process: xenobiotic metabolic process
UniProt Protein Details:
NCBI Summary:
CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20177059]).[supplied by OMIM, Apr 2010]
