The CMBL Antibody (PACO08478) is a polyclonal antibody designed for research involving Carboxymethylenebutenolidase (CMBL), a critical enzyme involved in drug metabolism and detoxification pathways. This antibody, raised in rabbits, is highly specific for binding to human samples and has been validated for use in Western blotting applications. It enables the detection and analysis of CMBL protein expression in various tissues and cell types, making it an essential tool for studies in pharmacology and drug development.CMBL is known for its role in the metabolism of various drugs, including anticancer agents and antibiotics, as well as endogenous compounds like fatty acids and estrogens. Understanding the expression and activity of CMBL is crucial for predicting drug response and toxicity, as well as for developing personalized medicine approaches.
Research on CMBL also has implications for understanding drug interactions, drug resistance mechanisms, and optimizing therapeutic regimens in clinical practice.Overall, the CMBL Antibody (PACO08478) offers researchers a valuable tool for investigating the role of CMBL in drug metabolism, personalized medicine, and the development of novel therapeutic strategies. Its high specificity and sensitivity make it suitable for a wide range of experimental applications, making it a valuable asset for pharmacological and biomedical research.
CMBL: Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin. Belongs to the dienelactone hydrolase family.Protein type: Hydrolase; EC 3.1.-.-Chromosomal Location of Human Ortholog: 5p15.2Cellular Component: cytosolMolecular Function: hydrolase activityBiological Process: xenobiotic metabolic process
UniProt Protein Details:
NCBI Summary:
CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20177059]).[supplied by OMIM, Apr 2010]
