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Clusterin Monoclonal Antibody [P1A11AT] (CPAB0061)

SKU:
CPAB0061
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
P1A11AT
Applications:
WB
ELISA
IHC
€149
Frequently bought together:

Description

system_update_alt Datasheet

Clusterin Monoclonal Antibody [P1A11AT] (CPAB0061)

The Clusterin Antibody (CPAB0061) offered by AssayGenie is a valuable tool for researchers studying the clusterin protein, also known as apolipoprotein J. This antibody is produced in rabbits and specifically targets human clusterin, making it highly reactive and ideal for use in Western blotting applications.Clusterin is a multifunctional protein involved in various physiological processes, including lipid transport, apoptosis, and cell adhesion. It has been implicated in conditions such as Alzheimer's disease, cancer, and cardiovascular disorders, making it a promising target for therapeutic interventions.

The Clusterin Antibody is designed to detect and analyze clusterin expression in different cell types, providing researchers with valuable insights into its role in disease progression and potential treatment strategies.By utilizing the Clusterin Antibody, researchers can further explore the mechanisms of action of clusterin and its involvement in pathological conditions. This antibody is a reliable tool for immunology and cancer research, offering valuable information that can contribute to the development of novel therapeutic approaches targeting clusterin-related pathways.

Product Name:Clusterin Antibody
Product Sku:CPAB0061
Size:5μg
Host Species:Mouse
Immunogen:Anti-human Clusterin mAb, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with Recombinant human Clusterin amino acids 1-333 purified from Ecoli.
Clone:P1A11AT.
Reactivity:Human
Applications:Western Blot, ELISA, Immunohistochemistry
Purification Method:Clusterin antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG1
Background:Clusterin also named Apolipoprotein J (APO-J) is a 75-80 kD disulfide-linked heterodimeric protein containing about 30% of N-linked carbohydrate rich in sialic acid but truncated forms targeted to the nucleus have also been identified. The precursor polypeptide chain is cleaved proteolytically to remove the 22-mer secretory signal peptide and subsequently between residues 227/228 to generate the ? and ? chains. These are assembled in anti-parallel to give a heterodimeric molecule in which the cysteine-rich centers are linked by five disulfide bridges and are flanked by two predicted coiled-coil ? -helices and three predicted amphipathic a-helices. Across a broad range of species clusterin shows a high degree of sequence homology ranging from 70% to 80%. It is nearly ubiquitously expressed in most mammalian tissues and can be found in plasma, milk, urine, cerebrospinal fluid and semen. It is able to bind and form complexes with numerous partners such as immunoglobulins, lipids, heparin, b
Synonyms:CLI, AAG4, KUB1, SGP2, SGP-2, SP-40, TRPM2, MGC24903, Complement-associated protein SP-40,40, Complement cytolysis inhibitor, NA1/NA2, Apolipoprotein J, Apo-J, Testosterone-repressed prostate message 2, TRPM-2.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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