The CLUAP1 Polyclonal Antibody (PAC038414) is a valuable tool for researchers studying the CLUAP1 protein, known for its role in cilia formation and function. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.CLUPA1, a key player in the formation and maintenance of cilia, has implications in various cellular processes such as cell signaling, sensory perception, and cell motility. Dysregulation of cilia function has been linked to a range of diseases, including developmental disorders and cancer.
By using the CLUAP1 antibody, researchers can investigate the expression and localization of CLUAP1 in different cell types, advancing our understanding of cilia biology and its implications in disease pathology.The versatility of this antibody makes it well-suited for studies in cell biology, developmental biology, and cancer research. Its ability to detect and analyze CLUAP1 protein levels in various experimental settings provides a valuable tool for researchers seeking to unravel the complexities of cilia-related disorders and explore novel therapeutic strategies.
Antibody Name:
CLUAP1 Antibody (PACO38414)
Antibody SKU:
PACO38414
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Clusterin-associated protein 1 protein (161-413AA)
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO38414 at dilution of 1:100.
Background:
Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity).
Synonyms:
Clusterin-associated protein 1 (Qilin), CLUAP1, KIAA0643
UniProt Protein Function:
CLUAP1: a nuclear protein commonly upregulated in colon cancers. It encodes a nuclear protein of 413 amino acids containing a coiled-coil domain. Associated with nuclear clusterin in a yeast two-hybrid system. Its expression gradually increases in the late S to G2/M phases of cell cycle and it returns to the basal level in the G0/G1 phases. RNAi suppression of this gene resulted in growth retardation in the transfected cells. Chromosomal Location of Human Ortholog: 16p13.3Cellular Component: centrosome; cilium; intracellular membrane-bound organelle; nucleoplasmMolecular Function: protein bindingBiological Process: cilium biogenesis
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene contains a single coiled-coil region. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
