The CLUAP1 Polyclonal Antibody (PAC016046) is a valuable tool for researchers studying CLUAP1, a protein involved in ciliary function and cellular transport processes. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blotting and immunofluorescence assays.CLUAP1, also known as clusterin-associated protein 1, is essential for the assembly and function of cilia, which play a crucial role in cell signaling and movement. Dysregulation of ciliary function has been linked to various diseases, including ciliopathies and cancer.
The CLUAP1 antibody enables researchers to study the expression and localization of this protein in different cell types, aiding in the investigation of its role in cellular processes and disease pathology.With its high specificity and reliability in detecting CLUAP1, this antibody is a valuable tool for researchers in the fields of cell biology, genetics, and developmental biology. By understanding the function of CLUAP1, scientists can gain insights into the mechanisms underlying ciliary dysfunction and potentially identify new therapeutic targets for related disorders.
Antibody Name:
CLUAP1 Antibody (PACO16046)
Antibody SKU:
PACO16046
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human CLUAP1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO16046(CLUAP1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16046(CLUAP1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The protein encoded by this gene contains a single coiled-coil region. Alternative splicing results in multiple transcript variants and protein isoforms.
Synonyms:
clusterin associated protein 1
UniProt Protein Function:
CLUAP1: a nuclear protein commonly upregulated in colon cancers. It encodes a nuclear protein of 413 amino acids containing a coiled-coil domain. Associated with nuclear clusterin in a yeast two-hybrid system. Its expression gradually increases in the late S to G2/M phases of cell cycle and it returns to the basal level in the G0/G1 phases. RNAi suppression of this gene resulted in growth retardation in the transfected cells. Chromosomal Location of Human Ortholog: 16p13.3Cellular Component: centrosome; cilium; intracellular membrane-bound organelle; nucleoplasmMolecular Function: protein bindingBiological Process: cilium biogenesis
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene contains a single coiled-coil region. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
