The CLSTN1 Polyclonal Antibody (CAB15405) is a valuable tool for research involving CLSTN1, a cell adhesion molecule that plays a crucial role in synaptic function and neuronal development. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. It specifically binds to the CLSTN1 protein, allowing for precise detection and analysis in various cell types.CLSTN1, also known as calsyntenin-1, is integral to the formation and maintenance of synapses, which are essential for proper communication between neurons. Dysregulation of CLSTN1 has been implicated in neurological disorders such as Alzheimer's disease and autism spectrum disorders, highlighting the importance of studying this protein in neurobiology research.
By elucidating the mechanisms by which CLSTN1 functions, researchers can gain valuable insights into the pathophysiology of these conditions and potentially identify novel therapeutic targets.The CLSTN1 Polyclonal Antibody is a reliable tool for investigating the role of CLSTN1 in synaptic plasticity, memory formation, and neuronal connectivity. Its use in research studies on neurodevelopmental and neurodegenerative disorders can lead to a better understanding of the molecular pathways involved in these conditions, paving the way for the development of targeted treatments and interventions.
Product Name:
CLSTN1 Rabbit Polyclonal Antibody
SKU:
CAB15405
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 29-350 of human CLSTN1 (NP_055759.3).
Cell junction, Cell projection, Endoplasmic reticulum membrane, Golgi apparatus membrane, Nucleus, Single-pass type I membrane protein, postsynaptic cell membrane, synapse.
Calculated MW:
110kDa
Observed MW:
110kDa
This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is thought to bind to kinesin-1 motors to mediate the axonal anterograde transport of certain types of vesicle. Amyloid precursor protein (APP) is trafficked via these vesicles and so this protein is being investigated to see how it might contribute to the mechanisms underlying Alzheimer's disease. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
22883
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CLSTN1 Rabbit pAb (CAB15405) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
