The CLSPN Polyclonal Antibody (CAB17202) is a valuable tool for research involving the CLSPN protein, a key player in the DNA damage response pathway. This rabbit-derived antibody is highly specific for binding to human samples and has been validated for use in Western blot applications. By targeting the CLSPN protein, this antibody allows for the detection and analysis of CLSPN in various cell types, making it an ideal choice for studies in molecular biology and cancer research.CLSPN, also known as the Claspin protein, plays a crucial role in coordinating the cellular response to DNA damage, particularly in the activation of the checkpoint kinase pathway.
Its involvement in DNA damage repair and cell cycle regulation makes it a promising target for research into cancer therapies and genetic disorders. Studying the function of CLSPN can provide valuable insights into the mechanisms of DNA repair and cell cycle control, with potential implications for developing new treatment strategies.
Product Name:
CLSPN Rabbit Polyclonal Antibody
SKU:
CAB17202
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 650-750 of human CLSPN (NP_001177410.1).
The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
63967
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CLSPN Rabbit pAb (CAB17202) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 150s.
