The CLRN2 Polyclonal Antibody (PAC025809) is a vital tool for researchers studying CLRN2, a protein associated with Usher syndrome, a genetic disorder that causes deafness and vision loss. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in immunofluorescence and immunohistochemistry applications.CLRN2, also known as Clarin-2, is a transmembrane protein found in sensory cells of the inner ear and retina, where it plays a crucial role in signal transduction and maintenance of sensory cell function.
Research on CLRN2 is essential for gaining insights into the molecular mechanisms underlying Usher syndrome and developing potential therapies for this debilitating condition.By targeting CLRN2, researchers can investigate the role of this protein in sensory cell function and identify potential therapeutic strategies for treating Usher syndrome. The CLRN2 Polyclonal Antibody is a valuable tool for advancing our understanding of this complex disease and exploring new avenues for intervention.
Immunohistochemistry of paraffin-embedded human liver tissue using PACO25809 at dilution of 1:100.
Immunofluorescence staining of U251 cells with PACO25809 at 1:150, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human lung tissue using PACO25809 at dilution of 1:100.
Synonyms:
Clarin-2, CLRN2
UniProt Protein Function:
CLRN2: a member of the clarin family of genes. The clarins appear to belong to a large superfamily of small integral membrane glycoproteins with four transmembrane domains. The exact function of this gene is unknown. [provided by RefSeq, Oct 2008]Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 4p15.32Cellular Component: integral to membrane
UniProt Protein Details:
NCBI Summary:
This gene belongs to the clarin family of genes. The clarins appear to belong to a large superfamily of small integral membrane glycoproteins with four transmembrane domains. The exact function of this gene is unknown. [provided by RefSeq, Oct 2008]
