CLOCK Rabbit Polyclonal Antibody (CAB5633)
- SKU:
- CAB5633
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | CLOCK Rabbit Polyclonal Antibody |
SKU: | CAB5633 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 450-600 of human CLOCK (NP_004889.1). |
Sequence: | STPT KIPT DTST PPRQ HLPA HEKM VQRR SSFS SQSI NSQS VGSS LTQP VMSQ ATNL PIPQ GMSQ FQFS AQLG AMQH LKDQ LEQR TRMI EANI HRQQ EELR KIQE QLQM VHGQ GLQM FLQQ SNPG LNFG SVQL SSGN SSNI QQLA PINM QGQ |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | KAT13D; bHLHe8; CLOCK |
Positive Sample: | HepG2,A-549,SH-SY5Y,Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 95kDa |
Observed MW: | 110kDa |
The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 9575 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |