The CLNS1A Polyclonal Antibody (CAB9739) is a valuable tool for researchers studying CLNS1A, a protein involved in cellular function and neurological disorders. This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to CLNS1A, researchers can accurately detect and analyze this protein in various cell types, making it an essential component for studies in neuroscience and neurodegenerative diseases.CLNS1A, also known as Battenin, is essential for normal cellular function in the brain and nervous system. Mutations in the CLNS1A gene have been linked to Batten disease, a rare and fatal neurodegenerative disorder that affects children.
Studying the role of CLNS1A in cellular processes and disease pathology is crucial for developing potential therapies and interventions for Batten disease and other neurological conditions.By utilizing the CLNS1A Polyclonal Antibody, researchers can gain valuable insights into the function and dysfunction of CLNS1A in both normal and disease states. This antibody offers a reliable and sensitive tool for investigating the molecular mechanisms of CLNS1A-related disorders, ultimately advancing our understanding of neurological diseases and paving the way for new treatment strategies.
Product Name:
CLNS1A Rabbit Polyclonal Antibody
SKU:
CAB9739
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-237 of human CLNS1A (NP_001284.1).
This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1207
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CLNS1A Rabbit pAb (CAB9739) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
