The CLN5 Polyclonal Antibody (CAB12886) is a valuable tool for researchers studying CLN5, a protein associated with neuronal ceroid lipofuscinoses (NCL), a group of neurodegenerative disorders. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the CLN5 protein, this antibody enables the detection and analysis of CLN5 in various cell types, making it ideal for investigations in neurology and genetic disorders.
CLN5 is a lysosomal protein involved in the degradation of cellular waste, and mutations in the CLN5 gene lead to the accumulation of toxic substances in cells, causing NCL. Understanding the role of CLN5 in cellular function is crucial for unraveling the mechanisms underlying NCL and developing potential therapies for this devastating disease. The CLN5 Polyclonal Antibody is a valuable tool for advancing research in this field and holds promise for improving the diagnosis and treatment of NCL.
Product Name:
CLN5 Rabbit Polyclonal Antibody
SKU:
CAB12886
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 96-407 of human CLN5 (NP_006484.1).
This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function.
Purification Method:
Affinity purification
Gene ID:
1203
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CLN5 Rabbit pAb (CAB12886) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
