The CLK4 Antibody (PACO00613) is a highly specific polyclonal antibody designed for use in research involving CDC-like kinase 4 (CLK4), a protein kinase involved in regulating pre-mRNA alternative splicing. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.CLK4 plays a crucial role in modulating the splicing patterns of target genes, ultimately influencing cellular functions such as cell cycle progression, apoptosis, and differentiation. Dysregulation of CLK4 has been implicated in various diseases, including cancer and neurological disorders, making it a promising therapeutic target for drug development.
With the CLK4 Antibody, researchers can accurately detect and analyze CLK4 protein levels in different cell types and tissues, providing valuable insight into the role of CLK4 in various biological processes. This antibody is a valuable tool for studies in molecular biology, biochemistry, and drug discovery, advancing our understanding of CLK4 function and its potential implications in disease pathology.
Antibody Name:
CLK4 Antibody
Antibody SKU:
PACO00613
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human CLK4.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CLK4; Dual specificity protein kinase CLK4; CDC-like kinase 4
UniProt Protein Function:
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]
