The Clip3 Polyclonal Antibody (PACO00611) is a versatile tool for researchers studying the Clip3 protein, a key player in cellular processes such as membrane trafficking and vesicular transport. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the Clip3 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential tool for studies in cell biology and molecular biology.Clip3, also known as CAP-Gly domain-containing linker protein 3, is involved in the regulation of microtubule dynamics and is essential for proper cell division and intracellular transport.
Dysfunction of Clip3 has been linked to diseases such as cancer and neurological disorders, highlighting the importance of studying this protein in various research fields. The Clip3 Polyclonal Antibody offers researchers a reliable means of investigating the role of Clip3 in cellular processes and disease pathways, ultimately aiding in the development of novel therapeutic strategies.
Antibody Name:
CLIP3 Antibody
Antibody SKU:
PACO00611
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC, IF
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human CLIP3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CLIP3; CLIPR59; CAP-Gly domain-containing linker protein 3; Cytoplasmic linker protein 170-related 59 kDa protein; CLIP-170-related 59 kDa protein; CLIPR-59
UniProt Protein Function:
CLIPR-59: Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics.Protein type: Unknown functionChromosomal Location of Human Ortholog: 19q13.12Cellular Component: cytosol; early endosome membrane; lipid raft; plasma membrane; recycling endosome membrane; trans-Golgi network; trans-Golgi network membraneMolecular Function: microtubule bindingBiological Process: fat cell differentiation; negative regulation of microtubule polymerization; peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine; positive regulation of apoptosis; positive regulation of endocytosis; positive regulation of protein amino acid phosphorylation
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
