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CLIP2 Antibody (PACO59397)

SKU:
PACO59397
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • CLIP2 Antibody PACO59397
  • CLIP2 Antibody PACO59397
€339

Description

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CLIP2 Antibody (PACO59397)

The Clip2 Polyclonal Antibody (PACO59397) is a high-quality antibody designed for research involving Clip2, a protein essential for microtubule organization and cell division. This antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in various applications, including Western blot and immunofluorescence.Clip2 plays a crucial role in regulating microtubule dynamics, which are essential for cell shape, motility, and intracellular transport. Dysregulation of Clip2 has been implicated in diseases such as cancer and neurodegenerative disorders, making it a valuable target for research aimed at understanding disease mechanisms and identifying potential therapeutic interventions.

With its ability to specifically bind to Clip2 protein, this antibody enables researchers to detect and analyze Clip2 expression in different cell types and tissues, making it a versatile tool for studies in cell biology, cancer research, and drug discovery. By investigating the functions of Clip2, scientists can gain insights into the underlying mechanisms of disease and potentially develop novel treatment strategies targeting this protein.

Antibody Name:CLIP2 Antibody (PACO59397)
Antibody SKU:PACO59397
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IF
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:200
Species Reactivity:Human, Mouse, Rat
Immunogen:Recombinant Human CAP-Gly domain-containing linker protein 2 protein (101-217AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern Blot. Positive WB detected in: Rat brain tissue, Mouse brain tissue. All lanes: CLIP2 antibody at 3.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 116, 112 kDa. Observed band size: 116 kDa.
Product ImageImmunofluorescence staining of A549 cells with PACO59397 at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity).
Synonyms:CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein), CLIP2, CYLN2 KIAA0291 WBSCR3 WBSCR4 WSCR4
UniProt Protein Function:CYLN2: Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations. CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; CytoskeletalChromosomal Location of Human Ortholog: 7q11.23Cellular Component: microtubule associated complex
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene belongs to the family of cytoplasmic linker proteins, which have been proposed to mediate the interaction between specific membranous organelles and microtubules. This protein was found to associate with both microtubules and an organelle called the dendritic lamellar body. This gene is hemizygously deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UDT6
NCBI GenInfo Identifier:74753268
NCBI Gene ID:7461
NCBI Accession:Q9UDT6.1
UniProt Secondary Accession:Q9UDT6,O14527, O43611
UniProt Related Accession:Q9UDT6
Molecular Weight:111,782 Da
NCBI Full Name:CAP-Gly domain-containing linker protein 2
NCBI Synonym Full Names:CAP-Gly domain containing linker protein 2
NCBI Official Symbol:CLIP2  
NCBI Official Synonym Symbols:CLIP; CYLN2; WSCR3; WSCR4; WBSCR3; WBSCR4; CLIP-115  
NCBI Protein Information:CAP-Gly domain-containing linker protein 2
UniProt Protein Name:CAP-Gly domain-containing linker protein 2
UniProt Synonym Protein Names:Cytoplasmic linker protein 115; CLIP-115; Cytoplasmic linker protein 2; Williams-Beuren syndrome chromosomal region 3 protein; Williams-Beuren syndrome chromosomal region 4 protein
Protein Family:CAP-Gly domain-containing linker protein
UniProt Gene Name:CLIP2  
UniProt Entry Name:CLIP2_HUMAN
Antibodies
CLIP2 Antibody (PACO06358)
Secondary Antibody
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