CLIP2 Antibody (PACO59397)
- SKU:
- PACO59397
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | CLIP2 Antibody (PACO59397) |
| Antibody SKU: | PACO59397 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant Human CAP-Gly domain-containing linker protein 2 protein (101-217AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Rat brain tissue, Mouse brain tissue. All lanes: CLIP2 antibody at 3.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 116, 112 kDa. Observed band size: 116 kDa. |
 | Immunofluorescence staining of A549 cells with PACO59397 at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). |
| Synonyms: | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) (Williams-Beuren syndrome chromosomal region 3 protein) (Williams-Beuren syndrome chromosomal region 4 protein), CLIP2, CYLN2 KIAA0291 WBSCR3 WBSCR4 WSCR4 |
| UniProt Protein Function: | CYLN2: Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations. CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; CytoskeletalChromosomal Location of Human Ortholog: 7q11.23Cellular Component: microtubule associated complex |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene belongs to the family of cytoplasmic linker proteins, which have been proposed to mediate the interaction between specific membranous organelles and microtubules. This protein was found to associate with both microtubules and an organelle called the dendritic lamellar body. This gene is hemizygously deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UDT6 |
| NCBI GenInfo Identifier: | 74753268 |
| NCBI Gene ID: | 7461 |
| NCBI Accession: | Q9UDT6.1 |
| UniProt Secondary Accession: | Q9UDT6,O14527, O43611 |
| UniProt Related Accession: | Q9UDT6 |
| Molecular Weight: | 111,782 Da |
| NCBI Full Name: | CAP-Gly domain-containing linker protein 2 |
| NCBI Synonym Full Names: | CAP-Gly domain containing linker protein 2 |
| NCBI Official Symbol: | CLIP2Â Â |
| NCBI Official Synonym Symbols: | CLIP; CYLN2; WSCR3; WSCR4; WBSCR3; WBSCR4; CLIP-115Â Â |
| NCBI Protein Information: | CAP-Gly domain-containing linker protein 2 |
| UniProt Protein Name: | CAP-Gly domain-containing linker protein 2 |
| UniProt Synonym Protein Names: | Cytoplasmic linker protein 115; CLIP-115; Cytoplasmic linker protein 2; Williams-Beuren syndrome chromosomal region 3 protein; Williams-Beuren syndrome chromosomal region 4 protein |
| Protein Family: | CAP-Gly domain-containing linker protein |
| UniProt Gene Name: | CLIP2Â Â |
| UniProt Entry Name: | CLIP2_HUMAN |
| Antibodies |
| CLIP2 Antibody (PACO06358) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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