The CLIP2 Polyclonal Antibody (PACO22225) is a valuable tool for researchers studying CLIP2, a key protein involved in microtubule dynamics and cell division. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting. By specifically binding to the CLIP2 protein, this antibody enables precise detection and analysis in different cell types, making it an essential resource for studies in cell biology and cancer research.CLIP2, also known as CAP-Gly domain-containing linker protein 2, plays a crucial role in organizing microtubules and facilitating chromosome segregation during cell division.
Its involvement in these processes makes it a promising target for research on cancer development and progression. Understanding the functions of CLIP2 is essential for unraveling the mechanisms underlying cellular proliferation and potentially identifying new therapeutic strategies for treating cancer.Overall, the CLIP2 Polyclonal Antibody (PACO22225) offers researchers a reliable tool for investigating the roles of CLIP2 in various cellular processes, providing valuable insights into its implications for cancer biology and potential therapeutic interventions.
Antibody Name:
CLIP2 Antibody (PACO22225)
Antibody SKU:
PACO22225
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from C-terminal of human CLIP2.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HepG2 cells and A549 cells, using CLIP2 antibody.
Background:
Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations By similarity.
Synonyms:
CAP-Gly domain-containing linker protein 2; Cytoplasmic linker protein 115; CLIP-115; Cytoplasmic linker protein 2; Williams-Beuren syndrome chromosomal region 3 protein
UniProt Protein Function:
CYLN2: Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations. CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; CytoskeletalChromosomal Location of Human Ortholog: 7q11.23Cellular Component: microtubule associated complex
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the family of cytoplasmic linker proteins, which have been proposed to mediate the interaction between specific membranous organelles and microtubules. This protein was found to associate with both microtubules and an organelle called the dendritic lamellar body. This gene is hemizygously deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
CLIP; CYLN2; WSCR3; WSCR4; WBSCR3; WBSCR4; CLIP-115Â Â
NCBI Protein Information:
CAP-Gly domain-containing linker protein 2
UniProt Protein Name:
CAP-Gly domain-containing linker protein 2
UniProt Synonym Protein Names:
Cytoplasmic linker protein 115; CLIP-115; Cytoplasmic linker protein 2; Williams-Beuren syndrome chromosomal region 3 protein; Williams-Beuren syndrome chromosomal region 4 protein
