The Clip2 Polyclonal Antibody (PACO06358) is a high-quality research tool specifically designed for the detection of Clip2 protein in various samples. Clip2 is a microtubule-binding protein involved in cell division and migration processes, making it a crucial target for studies in cell biology and cancer research.Raised in rabbits, this antibody demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding to the Clip2 protein, this antibody enables accurate detection and analysis in different cell types, allowing researchers to explore the role of Clip2 in cellular processes and its potential as a therapeutic target in cancer treatment.
The importance of Clip2 in regulating cell division and movement highlights its relevance in understanding cancer progression and metastasis. By studying the function of Clip2 using this antibody, researchers can gain insights into the mechanisms underlying tumor growth and invasion, ultimately contributing to the development of novel anti-cancer strategies.
Antibody Name:
CLIP2 Antibody (PACO06358)
Antibody SKU:
PACO06358
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:5000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from the C-terminal region of human CLIP-115.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of NIH-3T3 LOVO cells using CLIP-115 Polyclonal Antibody.
Western Blot analysis of A549 cells using CLIP-115 Polyclonal Antibody.
Synonyms:
CLIP2; CYLN2; KIAA0291; WBSCR3; WBSCR4; WSCR4; CAP-Gly domain-containing linker protein 2; Cytoplasmic linker protein 115; CLIP-115; Cytoplasmic linker protein 2; Williams-Beuren syndrome chromosomal region 3 protein; Williams-Beuren syndro
UniProt Protein Function:
CYLN2: Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations. CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; CytoskeletalChromosomal Location of Human Ortholog: 7q11.23Cellular Component: microtubule associated complex
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the family of cytoplasmic linker proteins, which have been proposed to mediate the interaction between specific membranous organelles and microtubules. This protein was found to associate with both microtubules and an organelle called the dendritic lamellar body. This gene is hemizygously deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
CLIP; CYLN2; WSCR3; WSCR4; WBSCR3; WBSCR4; CLIP-115Â Â
NCBI Protein Information:
CAP-Gly domain-containing linker protein 2
UniProt Protein Name:
CAP-Gly domain-containing linker protein 2
UniProt Synonym Protein Names:
Cytoplasmic linker protein 115; CLIP-115; Cytoplasmic linker protein 2; Williams-Beuren syndrome chromosomal region 3 protein; Williams-Beuren syndrome chromosomal region 4 protein
