The CLIC6 Antibody (PAC022264) is a valuable tool for researchers studying CLIC6, a member of the chloride intracellular channel (CLIC) family associated with various cellular functions. This polyclonal antibody is generated in rabbits and exhibits high reactivity with human samples, making it suitable for Western blot analysis.CLIC6 is known to be involved in intracellular chloride ion transport and has been implicated in processes such as cell proliferation, differentiation, and apoptosis. Research into CLIC6's role in cancer and other diseases has shown its potential as a therapeutic target, highlighting the importance of understanding its function.
By using the CLIC6 Antibody, researchers can effectively study the expression and localization of CLIC6 in different cell types, paving the way for in-depth investigations into its molecular mechanisms and potential implications in various physiological and pathological conditions. This antibody is a valuable tool for advancing our understanding of CLIC6 biology and its impact on human health.
Antibody Name:
CLIC6 Antibody (PACO22264)
Antibody SKU:
PACO22264
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human CLIC6.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HepG2 cells, using CLIC6 antibody.
Background:
May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport By similarity.
CLIC6: May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport. Belongs to the chloride channel CLIC family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Channel, chloride; Membrane protein, integralChromosomal Location of Human Ortholog: 21q22.12Cellular Component: cytoplasm; nucleusMolecular Function: chloride channel activity; glutathione transferase activityBiological Process: glutathione metabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015]
