CLIC2 Antibody (PACO25805)
- SKU:
- PACO25805
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CLIC2 Antibody (PACO25805)
The CLIC2 Polyclonal Antibody (PAC025805) is a valuable tool for researchers studying CLIC2, a protein involved in various cellular processes such as ion channel regulation and cell cycle control. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blotting applications. By specifically binding to the CLIC2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in cell biology and cancer research.CLIC2, also referred to as the chloride intracellular channel protein 2, plays a crucial role in maintaining cellular homeostasis by regulating ion transport and promoting cell proliferation.
Its involvement in these fundamental processes makes it a promising target for research on conditions such as cancer, neurological disorders, and cardiovascular diseases. By investigating the function of CLIC2, researchers can gain valuable insights into cellular mechanisms and potentially develop novel therapeutic strategies for treating related pathologies.
| Antibody Name: | CLIC2 Antibody (PACO25805) |
| Antibody SKU: | PACO25805 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Chloride intracellular channel protein 2 protein (53-247AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO25805 at dilution of 1:100. |
 | Western Blot Positive WB detected in: K562 whole cell lysate All lanes: CLIC2 antibody at 2µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 29 kDa Observed band size: 29 kDa . |
 | Immunofluorescent analysis of HepG2 cells using PACO25805 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. |
| Synonyms: | Chloride intracellular channel protein 2 (XAP121), CLIC2 |
| UniProt Protein Function: | CLIC2: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. Belongs to the chloride channel CLIC family.Protein type: Channel, chloride; Membrane protein, integralChromosomal Location of Human Ortholog: Xq28Cellular Component: cytoplasm; intracellular; nucleusMolecular Function: glutathione peroxidase activity; glutathione transferase activity; protein bindingBiological Process: glutathione metabolic process; positive regulation of binding; signal transduction; transportDisease: Mental Retardation, X-linked, Syndromic 32 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a chloride intracellular channel protein. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. This protein may play a role in inhibiting the function of ryanodine receptor 2. A mutation in this gene is the cause of X-linked mental retardation-32. [provided by RefSeq, Aug 2013] |
| UniProt Code: | O15247 |
| NCBI GenInfo Identifier: | 85681058 |
| NCBI Gene ID: | 1193 |
| NCBI Accession: | O15247.3 |
| UniProt Secondary Accession: | O15247,O15174, Q5JT80, Q8TCE3, A8K9S0 |
| UniProt Related Accession: | O15247 |
| Molecular Weight: | 28,356 Da |
| NCBI Full Name: | Chloride intracellular channel protein 2 |
| NCBI Synonym Full Names: | chloride intracellular channel 2 |
| NCBI Official Symbol: | CLIC2Â Â |
| NCBI Official Synonym Symbols: | CLIC2b; MRXS32; XAP121Â Â |
| NCBI Protein Information: | chloride intracellular channel protein 2 |
| UniProt Protein Name: | Chloride intracellular channel protein 2 |
| UniProt Synonym Protein Names: | XAP121 |
| Protein Family: | Chloride intracellular channel protein |
| UniProt Gene Name: | CLIC2Â Â |
| UniProt Entry Name: | CLIC2_HUMAN |
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