The CLIC1 Polyclonal Antibody (CAB13684) is a valuable tool for researchers studying CLIC1, a chloride intracellular channel protein involved in regulating cell volume and membrane potential. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the CLIC1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in cell biology and neuroscience.
CLIC1 plays a crucial role in various cellular processes, including cell proliferation, apoptosis, and ion transport. Dysregulation of CLIC1 has been linked to diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases. Research on CLIC1 using this antibody can provide insights into the mechanisms underlying these conditions and may lead to the development of novel therapeutic approaches targeting CLIC1.
Product Name:
CLIC1 Rabbit Polyclonal Antibody
SKU:
CAB13684
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 42-241 of human CLIC1 (NP_001279.2).
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.
Purification Method:
Affinity purification
Gene ID:
1192
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CLIC1 antibody (CAB13684) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
