The Clec9A Polyclonal Antibody (PACO46643) is a valuable tool for researchers studying Clec9A, a C-type lectin receptor expressed on dendritic cells that plays a crucial role in the immune response. This antibody, conjugated with HRP for enhanced detection, is raised in rabbits and exhibits high reactivity with human samples. It has been validated for use in various applications, including Western blot and immunohistochemistry.Clec9A is known to play a key role in antigen uptake and presentation, as well as in the activation of T cells. Its involvement in immune signaling pathways makes it a promising target for further research in immunology and cancer immunotherapy.
The Clec9A Polyclonal Antibody enables the specific detection and analysis of Clec9A protein levels in different cell types, facilitating a deeper understanding of its function and potential therapeutic applications.For researchers looking to explore the role of Clec9A in immune regulation and response, the Clec9A Polyclonal Antibody provides a reliable and sensitive tool for their studies. Its ability to detect and quantify Clec9A protein expression opens up new possibilities for investigating the mechanisms underlying immune activation and immune cell interactions, paving the way for advancements in cancer treatment and vaccine development.
Antibody Name:
CLEC9A Antibody, HRP conjugated (PACO46643)
Antibody SKU:
PACO46643
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human C-type lectin domain family 9 member A protein (103-214AA)
Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.
Synonyms:
C-type lectin domain family 9 member A, CLEC9A
UniProt Protein Function:
CLEC9A: Functions as an endocytic receptor on a small subset of myeloid cells and induces intracellular signaling via spleen tyrosine kinase (Syk). Acts as a receptor for necrotic cells and can mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.Protein type: Membrane protein, integral; Receptor, misc.Chromosomal Location of Human Ortholog: 12p13.2Cellular Component: cell surfaceBiological Process: positive regulation of cytokine secretion; receptor-mediated endocytosis
UniProt Protein Details:
NCBI Summary:
CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008]
