The CLEC9A Antibody (FITC-conjugated) is a specialized tool designed for researchers studying CLEC9A, a cell surface receptor involved in dendritic cell activation and antigen presentation. This antibody, conjugated with FITC for fluorescent detection, is produced in rabbits and has been validated for use in flow cytometry and immunofluorescence applications.CLEC9A is a key player in the immune system, specifically in the recognition and uptake of pathogens by dendritic cells. By targeting CLEC9A with this antibody, researchers can monitor and analyze the expression and localization of CLEC9A in various cell types, providing valuable insights into dendritic cell function and immune responses.
The use of the CLEC9A Antibody (FITC-conjugated) is particularly beneficial for studies in immunology, vaccine development, and infectious diseases. Its ability to specifically detect CLEC9A can help researchers better understand the mechanisms underlying immune responses and potentially identify new therapeutic targets for immune-related disorders.Overall, this antibody offers a reliable and sensitive tool for investigating the role of CLEC9A in immune regulation and dendritic cell function, making it a valuable asset for researchers in the field of immunology.
Antibody Name:
CLEC9A Antibody, FITC conjugated (PACO46644)
Antibody SKU:
PACO46644
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human C-type lectin domain family 9 member A protein (103-214AA)
Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.
Synonyms:
C-type lectin domain family 9 member A, CLEC9A
UniProt Protein Function:
CLEC9A: Functions as an endocytic receptor on a small subset of myeloid cells and induces intracellular signaling via spleen tyrosine kinase (Syk). Acts as a receptor for necrotic cells and can mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.Protein type: Membrane protein, integral; Receptor, misc.Chromosomal Location of Human Ortholog: 12p13.2Cellular Component: cell surfaceBiological Process: positive regulation of cytokine secretion; receptor-mediated endocytosis
UniProt Protein Details:
NCBI Summary:
CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008]
