The CLEC9A Antibody (Biotin Conjugated) is a valuable tool for researchers studying the CLEC9A protein, a key molecule involved in dendritic cell function and antigen presentation. This polyclonal antibody, conjugated to biotin for easy detection, is raised in rabbits and highly specific to human samples.CLEC9A is known for its role in recognizing necrotic cells and viral particles, contributing to immune responses and shaping adaptive immunity. This antibody is validated for use in applications such as Western blot and immunofluorescence, allowing for the detection and analysis of CLEC9A in various cell types.
With its ability to target CLEC9A, researchers can further explore the functions and interactions of this receptor in immune responses, making it a valuable tool for studies in immunology, infection, and vaccine development. Understanding the role of CLEC9A can provide insights into dendritic cell function and potential therapeutic strategies for immune-related disorders.
Antibody Name:
CLEC9A Antibody, Biotin conjugated (PACO46645)
Antibody SKU:
PACO46645
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human C-type lectin domain family 9 member A protein (103-214AA)
Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.
Synonyms:
C-type lectin domain family 9 member A, CLEC9A
UniProt Protein Function:
CLEC9A: Functions as an endocytic receptor on a small subset of myeloid cells and induces intracellular signaling via spleen tyrosine kinase (Syk). Acts as a receptor for necrotic cells and can mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.Protein type: Membrane protein, integral; Receptor, misc.Chromosomal Location of Human Ortholog: 12p13.2Cellular Component: cell surfaceBiological Process: positive regulation of cytokine secretion; receptor-mediated endocytosis
UniProt Protein Details:
NCBI Summary:
CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008]
