The CLEC6A Polyclonal Antibody (PACO19556) is a valuable tool for researchers studying CLEC6A, a type II transmembrane receptor belonging to the C-type lectin superfamily. This antibody, developed in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the CLEC6A protein, this antibody allows for precise detection and analysis in a variety of cell types, making it ideal for investigations in immunology and cancer research.CLEC6A, also known as Dectin-2, is involved in immune regulation and plays a critical role in recognizing and responding to pathogens.
Its function in immune response modulation makes it a promising target for research into infectious diseases, autoimmune disorders, and inflammatory conditions. Understanding the mechanisms of CLEC6A activity is key to developing targeted therapies that manipulate immune responses in these contexts. The CLEC6A Polyclonal Antibody (PACO19556) offers researchers a reliable tool for studying the functions and interactions of CLEC6A in various biological processes, ultimately contributing to advancements in our understanding of immune regulation and the development of potential therapeutic strategies.
Antibody Name:
CLEC6A Antibody (PACO19556)
Antibody SKU:
PACO19556
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human CLEC6A
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19556(CLEC6A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Like dectin-1 (CLEC7A; MIM 606264), CLEC6A, or dectin-2, is a type II membrane receptor with an extracellular C-type lectin-like domain fold. However, unlike dectin-1, dectin-2 lacks an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain
Synonyms:
C-type lectin domain family 6, member A
UniProt Protein Function:
dectin-2: Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptative immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 12p13Cellular Component: plasma membraneMolecular Function: carbohydrate bindingBiological Process: defense response to fungus; innate immune response; positive regulation of cytokine secretion; positive regulation of I-kappaB kinase/NF-kappaB cascade; stimulatory C-type lectin receptor signaling pathway
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
